Interferon Beta-1a

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Interferon Beta-1a

 Actions
 Indications
 Contraindications
 Route/Dosage
 Interactions
 Lab Test Interferences
 Adverse Reactions
 Precautions
Patient Care Considerations
 Administration/Storage
 Assessment/Interventions
 Patient/Family Education


(In-ter-FEER-ahn BAY-tah 1a)
Avonex
Powder for Injection, lyophilized: 33 mcg (6.6 million IU)
Rebif
Powder for injection: 22 mcg
Powder for injection: 44 mcg
Class: Interferon
Immunomodulator

 Action Has antiviral, antiproliferative, and immunoregulatory activities. Binds to specific cell membrane receptors that induce the expression of a number of gene products that mediate the biological actions of interferon beta-1a.

 Indications Treatment of relapsing forms of multiple sclerosis to slow accumulation of physical disability and decrease the frequency of clinical exacerbations.

 Contraindications Hypersensitivity to natural or recombinant interferon beta, human albumin, or any other component of the formulation.

 Route/Dosage

Adults: Avonex: IM 30 mcg once weekly. Rebif: SC 44 mcg 3 times/wk.

 Interactions

Live Virus Vaccines (eg, Measles, Mumps, Polio, Rubella): May inhibit antibody response after immunization; avoid concurrent use.

 Lab Test Interferences None well documented.

 Adverse Reactions

CARDIOVASCULAR: Syncope; vasodilation. CNS: Headache; asthenia; malaise; depression; sleep difficulty; dizziness; muscle spasm; speech disorder; seizures; ataxia. DERMATOLOGIC: Urticaria; alopecia; nevus; herpes zoster; herpes simplex. EENT: Sinusitis; otitis media; decreased hearing. GI: Nausea; diarrhea; dyspepsia; abdominal pain; anorexia. GU: Vaginitis; ovarian cyst. HEMATOLOGIC: Anemia; eosinophilia. METABOLIC: Increased AST. RESPIRATORY: Upper respiratory tract infection; dyspnea. OTHER: Injection site reactions (eg, bruising, necrosis, inflammation, pain); flu-like symptoms (eg, fever, chills, myalgia); pain; chest or joint pain; hypersensitivity reactions; photosensitivity.

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy in children less than 18 yr not established. Suicide/Depression: Suicide attempts occurred in clinical trials. Report depression and suicidal ideation immediately. Seizures: Use caution when administering to patients with preexisting seizure disorder. Cardiac Disease: Interferon beta-1a-induced flu syndrome may prove stressful to patients with severe cardiac conditions (eg, CHF, arrhythmia, angina). Photosensitivity: May occur. Caution patient to use sunscreen (SPF 30 or more) and wear protective clothing until tolerance is determined.


PATIENT CARE CONSIDERATIONS


 Administration/Storage

 Assessment/Interventions

 Patient/Family Education

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Copyright
© 2003 Facts and Comparisons
David S. Tatro
A to Z Drug Facts